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Caltech

Organic Chemistry Seminar

Wednesday, October 2, 2024
4:00pm to 5:00pm
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Gates Annex B122
New Tools in the Toolbox for Green & Sustainable Organic Synthesis
Bruce Lipshutz, Professor, Department of Chemistry and Biochemistry, UC Santa Barbara,

Several new technologies will be presented, each having been developed in an environmentally responsible fashion. These will include, after some opening remarks, (1) a discussion on new amination reactions of non-PFAS pseudohalides, featuring a very effective, novel, and readily prepared oxidative addition complex (OAC) that leads to couplings in water at low loadings of Pd in minutes; (2) new chemistry in flow, using water, aimed at preparing products from SNAr reactions, and amides, quickly; (3) a new process for effecting Miyaura borylations and notably, their use in a 1-pot sequence involving aromatic/heteroaromatic borylations followed by Suzuki-Miyaura couplings, in 1-pot, and green.

For more information, please contact Annette Luymes by phone at x6016 or by email at [email protected].